. GAMMA.-Radiolysis of 1-substituted 5-fluorouracil derivatives.

…, K Hisamura, I Matsukuma, H Nishikawa…

Index: Kuroda, Tokuyuki; Hisamura, Koji; Matsukuma, Ikuo; Nishikawa, Hiroshi; Nakamizo, Nobuhiro Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 3 p. 674 - 681

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Citation Number: 4

Abstract

A new concept,“Radiation-Induced Drug (RID)”, was proposed as a novel type of drugs for cancer therapy. To test the usefulness of this concept, 5-fluorouracil (5-FU) derivatives having various types of substituents at the 1-position were prepared and the γ-radiolyses of their aqueous solutions were studied. The compounds having sulfonyl and thioureido groups as the substituents produced efficiently 5-FU with high G values upon γ-irradiation. ...