Nucleoside conjugates. 7. Synthesis and antitumor activity of 1-. beta.-D-arabinofuranosylcytosine conjugates of ether lipids

…, DJ Buchheit, A Nechaev, AJ Kirisits…

Index: Hong; An; Buchheit; Nechaev; Kirisits; West; Berdel Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2038 - 2044

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Citation Number: 53

Abstract

Among them, conjugate 9a produced significant increase in life span (200-293%) in mice bearing ip and ic implanted L1210 lymphoic leukemia at a total dose of 400-500 mg (406- 508 pmol/kg). Significant schedule dependence was not observed when the conjugate was Riven ip once daily on day 1, days 1, 5, and 9, and days 1-5. The new conjugates are water soluMe by sonication.