Tetrahedron letters

One-pot syntheses of 6-mercaptopurines (6MP) from 4, 5-diamino-6-chloro-pyrimidines

S Tandel, I Bliznets, K Ebinger, YA Ma, D Bhumralkar…

Index: Tandel, Sagun; Bliznets, Igor; Ebinger, Katalin; Ma, You-An; Bhumralkar, Dilip; Thiruvazhi, Mohan Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2321 - 2322

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Citation Number: 10

Abstract

In the past two decades, 6-mercaptopurine (6MP) and its analogues have been a synthetic target for SAR programs in therapeutic areas of cancer, 1 viral infections, 2 and in CNS as ligands for benzodiazepine receptors. 3 In one instance, there has been a report of it being clinically used in the treatment of leukemia. 1 In these reports, thiopurines are obtained by treating chloropurines with thiourea, [1], [3] and [4] NaSH/EtOH, 2 and in some cases with H 2 S/base. 5 These ...