Lipophilic 1, 3-xylyl-21-crown-6 macrocyclic polyether 2-carboxylic acids as biological mimics of the ionophore antibiotics

FJ Urban, LR Chappel, AE Girard…

Index: Urban, Frank J.; Chappel, Larry R.; Girard, Arthur E.; Mylari, Banavara L.; Pimblett, Ian J. Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 765 - 771

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Citation Number: 7

Abstract

Twelve lipophilic 1, 3-xylyl-21-crown-6 macrocyclic polyether 2-carboxylic acids (9a-91), two lariat ether 1, 3-xylyl-21-crown-6 macrocyclic polyether 2-carboxylic acids (21 and 22), and two 1, 3-xylyl-2&crown-8 macrocyclic polyether 2-carboxylic acids (loa and lob) were synthesized and tested for in vitro antibacterial activity, in vitro stimulation of rumen propionic acid production, and in vivo anticoccidial activity in chickens. These are biological screens ...