Organic letters

Direct glycosylation of unprotected and unactivated carbohydrates under mild conditions

M Pfaffe, R Mahrwald

Index: Pfaffe, Matthias; Mahrwald, Rainer Organic Letters, 2012 , vol. 14, # 3 p. 792 - 795

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Citation Number: 22

Abstract

Ligand exchange acetalization of acetals in the presence of catalytic amounts of mandelic acid and titanium tert-butoxide is reported. This transformation is successfully extended to glycosylation of unprotected and unactivated pentoses. Even unreactive pentoses such as d- arabinose or d-lyxose can be transformed by this new methodology into corresponding isopropyl glycosides.