Desaminogirollines syn 2′ S, 3′ S and 2′ R, 3′ R have been prepared from N1- camphosulfonamide 4-carboxaldehyde imidazole and their diastereoisomeric derivatives have been separated. The stereoselective synthesis of chiral natural girolline has been achieved from D (-) arabinose: this ose is condensed with formamidine acetate to obtain a 4 (5)-[1′, 2′, 3′-trihydroxypropyl]-imidazole; the side-chain is chlorinated before being ...
