Journal of medicinal chemistry

Potential antimitotic agents. Synthesis of some ethyl benzopyrazin-7-ylcarbamates, ethyl pyrido [3, 4-b] pyrazin-7-ylcarbamates, and ethyl pyrido [3, 4-e]-as-triazin-7- …

C Temple Jr, GA Rener

Index: Temple, Carroll; Rener, Gregory A. Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3044 - 3050

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Citation Number: 12

Abstract

NH2 H a a. EtO2CCOC6H, b. 4-MeC6H, S020CH (CN) C6H5, 16 was effected with the borane-methyl sulfide complex to give 22 (mass spectrum), which on purification underwent air oxidation to give 15. In a trial experiment, reduction of 15 with NaBH4-A1, O3 gave a 9: l mixture of 14-15. In a repeat of this reaction the product was isolated in the presence of ascorbic acid, but these conditions gave a 1: 2 mixture of 14-15.