Novel cAMP PDE III inhibitors: 1, 6-naphthyridin-2 (1H)-ones

…, GY Lesher, KC Pluncket, ED Pagani…

Index: Singh, Baldev; Lesher, George Y.; Pluncket, Kevin C.; Pagani, Edward D.; Bode, Donald C.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 26 p. 4858 - 4865

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Citation Number: 20

Abstract

Two series of medorinone (3) analogs were prepared by modifications at C (2) and C (5). The C (2)-series was prepared from 2-chloro-5-methyl-l, 6-naphthyridine (4) by replacement of the chloro group with various nucleophiles. The C (5)-series was prepared from 5-acyl-6- [2-(dimethylamino)-ethenyl]-2 (1H)-pyridinone (ll), 5-bromo-l, 6-naphthyridin-2 (1H)-one (171, and l, &diketones 19 and 27. 1, 6-Naphthyridin-2 (1H)-ones are novel inhibitors of ...