Il Farmaco

N-Acyl-N-phenyl ureas of piperidine and substituted piperidines endowed with anti-inflammatory and anti-proliferative activities

…, S Schenone, O Bruno, F Bondavalli, W Filippelli…

Index: Ranise, Angelo; Schenone, Silvia; Bruno, Olga; Bondavalli, Francesco; Filippelli, Walter; Falcone, Giuseppe; Rivaldi, Barbara Farmaco, 2001 , vol. 56, # 9 p. 647 - 657

Full Text: HTML

Citation Number: 18

Abstract

Six series of N-acyl-N-phenyl ureas 1–6 of piperidine (1), and 2-ethyl-(2), 3-methyl-(3), 4- methyl-(4), 4-phenyl-(5), cis-2, 6-dimethyl-(6) piperidine were synthesised and evaluated for their anti-inflammatory, anaesthetic, anti-pyretic properties. Some derivatives of series 1 and 5 were also assayed for anti-proliferative activity. Several compounds showed an anti- inflammatory activity comparable or slighty inferior to that of indomethacin in rats (1c, d, 2a ...