Iron??Catalyzed Tandem One??Pot Addition and Cyclization of the Blaise Reaction Intermediate and Nitroolefins: Synthesis of Substituted NH??Pyrroles from Nitriles

MN Zhao, H Liang, ZH Ren…

Index: Zhao, Mi-Na; Liang, Hao; Ren, Zhi-Hui; Guan, Zheng-Hui Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 221 - 226

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Citation Number: 20

Abstract

Abstract The iron-catalyzed addition and cyclization of the Blaise reaction intermediate and nitroolefins to synthesize highly functionalized NH-pyrroles in a tandem one-pot manner from nitriles has been developed. This reaction shows good functional group tolerance and affords a broad spectrum of substituted NH-pyrroles in good yields.

~40%

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