Acta Pol Pharm

Synthesis, antitubercular, antifungal and antibacterial activities of 6-substituted phenyl-2-(3í-substituted phenyl pyridazin-6í-yl)-2, 3, 4, 5-tetrahydropyridazin-3- …

M Islam, AA Siddiqui, R Rajesh

Index: Islam, Mojahidul; Siddiqui, Anees A.; Rajesh, Ramadoss Acta Poloniae Pharmaceutica - Drug Research, 2008 , vol. 65, # 3 p. 353 - 362

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Citation Number: 56

Abstract

Abstract: A series of 6-substituted phenyl-2-(3í-substituted phenyl pyridazin-6í-yl)-2, 3, 4, 5- tetrahydropyridazin-3-ones has been synthesized. An appropriate aromatic hydrocarbon reacts with succinic anhydride in presence of AlCl3 to yield β-aroyl propionic acid. The corresponding acid was cyclized with hydrazine hydrate to give 6-(substituted aryl)-2, 3, 4, 5- tetrahydro-3-pyridazinone, which was heated on steam bath with phosphorus (V) ...