Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands

…, JY Kim, ME Jung, K Ahn, SU Kim, J Kim, J Lee

Index: Song, Kwang-Seop; Lee, Sung-Han; Chun, Hyun Ji; Kim, Jong Yup; Jung, Myung Eun; Ahn, Kwangwoo; Kim, Soo-Un; Kim, Jeongmin; Lee, Jinhwa Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 7 p. 4035 - 4051

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Citation Number: 19

Abstract

After the CB1 receptor antagonist SR141716 (rimonabant) was previously reported to modulate food intake, CB1 antagonism has been considered as a new therapeutic target for the treatment of obesity. Several series of urea, carbamate, amide, sulfonamide and oxalamide derivatives based on 1-benzhydrylpiperazine scaffold were synthesized and tested for CB1 receptor binding affinity. The SAR studies to optimize the CB1 binding ...

89-98-5

2-Chlorobenzaldehyde

~74%

Convenient Synthesis of Structurally Novel 1, 3??Disubstitut...

[Kharul, Rajendra K.; Goswami, Amitgiri; Gite, Archana; Godha, Atul K.; Jain, Mukul; Patel, Pankaj R. Synthetic Communications, 2008 , vol. 38, # 11 p. 1703 - 1717]

Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted ...

[Roughley, Stephen D.; Browne, Helen; MacIas, Alba T.; Benwell, Karen; Brooks, Teresa; D'Alessandro, Jalanie; Daniels, Zoe; Dugdale, Sarah; Francis, Geraint; Gibbons, Ben; Hart, Terance; Haymes, Timothy; Kennett, Guy; Lightowler, Sean; Matassova, Natalia; Mansell, Howard; Merrett, Angela; Misra, Anil; Padfield, Anthony; Parsons, Rachel; Pratt, Robert; Robertson, Alan; Simmonite, Heather; Tan, Kiri; Walls, Steven B.; Wong, Melanie Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 901 - 906]