Conformational manifold of α-aminoisobutyric acid (Aib) containing alanine-based tripeptides in aqueous solution explored by vibrational spectroscopy, electronic …

R Schweitzer-Stenner, W Gonzales…

Index: Schweitzer-Stenner, Reinhard; Gonzales, Widalys; Bourne, Gregory T.; Feng, Jianwen A.; Marshall, Garland R. Journal of the American Chemical Society, 2007 , vol. 129, # 43 p. 13095 - 13109

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Citation Number: 34

Abstract

Replacement of the α-proton of an alanine residue to generate α-aminoisobutyric acid (Aib) in alanine-based oligopeptides favors the formation of a 310 helix when the length of the oligopeptide is about four to six residues. This research was aimed at experimentally identifying the structural impact of an individual Aib residue in an alanine context of short peptides in water and Aib's influence on the conformation of nearest-neighbor residues. ...