Biomacromolecules

Linear cationic click polymer for gene delivery: synthesis, biocompatibility, and in vitro transfection

Y Gao, L Chen, Z Zhang, W Gu, Y Li

Index: Gao, Yu; Chen, Lingli; Zhang, Zhiwen; Gu, Wangwen; Li, Yaping Biomacromolecules, 2010 , vol. 11, # 11 p. 3102 - 3111

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Citation Number: 20

Abstract

Sixteen novel cationic click polymers (CPs) were parallelly synthesized via the conjugation of four alkyne-functionalized monomers to four azide-functionalized monomers by “click chemistry”. The biocompatibility of CPs was evaluated by in vitro cytotoxicity (MTT assay, Hoechst/PI apoptosis/necrosis assay, and cell cycle analysis) and blood compatibility tests (hemolysis and erythrocyte aggregation). The experimental results showed that the kind of ...