Synthesis and diuretic action of substituted 2-butenolides-4

…, AS Kukharev, LA Melentovich, IG Tishchenko…

Index: Vlasov, S. F.; Zakharevskii, A. S.; Kukharev, A. S.; Melentovich, L. A.; Tishchenko, I. G.; et al. Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 10 p. 737 - 739 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 10 p. 1213 - 1216

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Abstract

With= he aim of finding new biologically active compounds in the series of functionalsubstituted unsaturated u we synthesized methyl-and phenyl-substituted 2- halogen-4-aminoethyl-2-butenolides-4 (VIIIa, b-XIVa, b) by heating, in an excess of hydrohalic acid, esters of the corresponding E-5-amino-4-hydroxy-2, 3-epoxyvaleric acids (I- VII) obtained by the method we suggested earlier [3].