THIONO COMPOUNDS, 7. OXIDATION OF THIOAMIDES IN RELATION TO ADVERSE BIOLOGICAL EFFECTS1

JH Hillhouse, IA Blair, L Field

Index: Hillhouse, John H.; Blair, Ian A.; Field, Lamar Phosphorus and Sulfur and the Related Elements, 1986 , vol. 26, p. 169 - 184

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Citation Number: 14

Abstract

Abstract Thioacetamide, thioacetamide S-oxide (1), and thiopivalamide S-oxide (8) were oxidized with H2O2 in H2 18O to generate the corresponding amides with at least 50% 18O incorporation; hydrolysis of the S-oxides to the amides or 18O exchange with the amides occurs much more slowly. When 1 and trifluorothioacetamide (6) were oxidized with three and four equivalents of H2O2, respectively, in the presence of benzylamine, N- ...