Synthesis and properties of 1??Benzothiopyrano [2, 3??d]??pyrimidine??2, 4??(3H) diones (10??thia??5??deazaflavins)

F Yoneda, K Tsukuda, M Kawazoe…

Index: Yoneda, Fumio; Tsukuda, Kinshiro; Kawazoe, Michiko; Sone, Atsuko; Koshiro, Akira Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1329 - 1334

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Citation Number: 10

Abstract

Abstract Treatment of 6-arylthiouracils with the Vilsmeier reagent (dimethylformamide- phosphorus oxychloride) gave the corresponding 6-arylthio-5-formyluracils, which could alternatively be prepared by the condensation of 6-chloro-5-formyluracils with thiophenols. Dehydrative cyclization of the above 5-formyluracils with polyphosphoric acid gave 1- benzothiopyrano [2, 3-d] pyrimidine-2, 4-(3H) diones (10-thia-5-deazaflavins). These 10- ...