Thieno [2, 3-d] pyrimidinedione derivatives as antibacterial agents

…, C Vidaillac, D Oupický, MJ Rybak, SM Firestine

Index: Dewal, Mahender B.; Wani, Amit S.; Vidaillac, Celine; Oupicky, David; Rybak, Michael J.; Firestine, Steven M. European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 145 - 153

Full Text: HTML

Citation Number: 20

Abstract

Several thieno [2, 3-d] pyrimidinediones have been synthesized and examined for antibacterial activity against a range of Gram-positive and Gram-negative pathogens. Two compounds displayed potent activity (2–16 mg/L) against multi-drug resistant Gram-positive organisms, including methicillin resistant, vancomycin-intermediate, vancomycin-resistant Staphylococcus aureus (MRSA, VISA, VRSA) and vancomycin-resistant enterococci (VRE ...