Journal of the American Chemical Society

The Synthesis of Nuclear Isomers of Quinacrine

WG Dauben

Index: Dauben Journal of the American Chemical Society, 1948 , vol. 70, p. 2420,2422

Full Text: HTML

Citation Number: 6

Abstract

CHaOO%\\"/c1 group in position two of the acridine nucleus and the chlorine atom in the opposite, nitrogen-free ring, only two have been reported. They are the 2-methoxy-6-chloro- 9-substituted-aminoacridine2 (Quinacrine) and the related 7-chloro i~ orner.~ The present paper is concerned with the synthesis of the 5-chloro and the 8-chloro isomer^.^ Following the observations of Ullmann and Kipper6 that 2-chloro-5-methoxybenzoic acida (I) can be ...