Index: Faul, Margaret M.; Engler, Thomas A.; Sullivan, Kevin A.; Grutsch, John L.; Clayton, Marcella T.; Martinelli, Michael J.; Pawlak, Joseph M.; LeTourneau, Michael; Coffey, D. Scott; Pedersen, Steven W.; Kolis, Stanley P.; Furness, Kelly; Malhotra, Sushant; Al-Awar, Rima S.; Ray, James E. Journal of Organic Chemistry, 2004 , vol. 69, # 9 p. 2967 - 2975
Synthesis of indolo [6, 7-a] pyrrolo [3, 4-c] carbazoles 1, a new class of cyclin D1/CDK4 inhibitors, by oxidation of the corresponding aryl indolylmaleimides 2, will be described. Two approaches to the synthesis of 2 were identified that required new methods for the synthesis of 7-substituted indole acetamides 3 and N-methyl (indol-7-yl) oxoacetates 6. The chemistry developed enabled introduction of functionality (-OR, NR2) at C12 and N13 facilitating ...
