Tunable Bromomagnesium Thiolate Tishchenko Reaction Catalysts: Intermolecular Aldehyde–Trifluoromethylketone Coupling

…, F Manoni, CJ O'Connor, SJ Connon

Index: Cronin, Linda; Manoni, Francesco; O'Connor, Cornelius J.; Connon, Stephen J. Angewandte Chemie - International Edition, 2010 , vol. 49, # 17 p. 3045 - 3048

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Citation Number: 37

Abstract

The Tishchenko reaction [1](discovered by Claisen [2] in 1887) is the disproportionation of two aldehyde molecules to furnish an ester product (Scheme 1).[3] Aluminum alkoxides [1, 4] and boric acid,[5] were the first classes of synthetically relevant homogeneous catalysts [6] for this reaction, these were then followed by a range of transition-metal complexes of low to high catalytic activity but often limited practical utility.[7, 8] More recently, lanthanide,[9] ...