Synthesis and Anti??Bacterial Activity of Some Heterocyclic Chalcone Derivatives Bearing Thiofuran, Furan, and Quinoline Moieties

CJ Zheng, SM Jiang, ZH Chen, BJ Ye…

Index: Zheng, Chang-Ji; Jiang, Sheng-Ming; Chen, Zhen-Hua; Ye, Bai-Jun; Piao, Hu-Ri Archiv der Pharmazie, 2011 , vol. 344, # 10 p. 689 - 695

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Citation Number: 27

Abstract

Abstract 36 Novel heterocyclic chalcone derivatives were synthesized and tested for their anti-bacterial activity. Some compounds presented good anti-microbial activities against Gram-positive bacteria (including the multidrug-resistant clinical isolates). This class of compounds presented high potency against Streptococcus mutans, among which the derivatives F2 with an MIC of 2 µg/mL was as active as the standard drug (norfloxacin) ...