Tetrahedron letters

Regioselective N-9 arylation of purines employing arylboronic acids in the presence of Cu (II)

AK Bakkestuen, LL Gundersen

Index: Bakkestuen, Anne Kristin; Gundersen, Lise-Lotte Tetrahedron Letters, 2003 , vol. 44, # 16 p. 3359 - 3362

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Citation Number: 65

Abstract

We have recently reported profound antimycobacterial activity for 6-aryl-9-benzylpurines as in compound 1 (Fig. 1), 10., and whereas the 9-phenylethylpurine derivative 2 was only moderately active. In order to gain further insight into the structural requirements for active antimycobacterial purines, we needed easy access to 9-arylpurines such as compound 3. ... Structure of known and potential antimycobacterial purines 1–3 as well as ... Structure of known and potential ...