Designing nootropic dipeptides using an evolutionary-genetic approach

…, SV Nikitin, RU Ostrovskaya, TA Voronina…

Index: Gudasheva, T. A.; Rozantsev, G. G.; Ostrovskaya, R. U.; Trofimov, S. S.; Voronina, T. A.; et al. Pharmaceutical Chemistry Journal, 1995 , vol. 29, # 1 p. 14 - 17 Khimiko-Farmatsevticheskii Zhurnal, 1995 , vol. 29, # 1 p. 15 - 18

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Abstract

Abstract A novel approach to the search for the new groups of biologically active peptides is developed, which is based on the selection of point mutants with respect to noncritical amino acid residues. Using a gene site encoding the arginine vasopressin AVP (4–5) sequence, which corresponds to the pGlu-Asn-NH 2 nootropic dipeptide, three point mutants with respect to Asn (pGlu-Ser-NH 2, pGlu-Asp-NH 2, and pGlu-His-NH 2) have been ...