Sequence-specific osmium reagents for polynucleotides. 2. A method for thymine-cytosine pairs

H Ford, CH Chang, EJ Behrman

Index: Ford, H.; Chang, C.-H.; Behrman, E.J. Journal of the American Chemical Society, 1981 , vol. 103, # 26 p. 7773 - 7779

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Citation Number: 17

Abstract

Abstract: We have modified the dinucleoside monophosphate, deoxythymidylyldeoxycytidine (d-TpC), by replacement of the exocyclic amino group of cytosine with a series of ligands, HzN (CHz),, N (CH3) CHzCHzN (CH3) z, where n= 2, 4, and 6. The kinetics of the reactions of these modified dinucleoside monophosphates with osmium tetroxide were measured. The modified nucleotides react with osmium tetroxide ...