Hybridizing ability and nuclease resistance profile of backbone modified cationic phosphorothioate oligonucleotides

SMA Rahman, T Baba, T Kodama, MA Islam…

Index: Rahman, S.M. Abdur; Baba, Takeshi; Kodama, Tetsuya; Islam, Md. Ariful; Obika, Satoshi Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 13 p. 4098 - 4102

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Citation Number: 9

Abstract

Various stereochemically pure cationic phosphorothioate oligonucleotides bearing aminoalkyl moieties were synthesized, and their duplex-forming ability against single- stranded DNA (ssDNA), single-stranded RNA (ssRNA) and triplex-forming ability against double-stranded DNA (dsDNA) were evaluated by UV melting experiments. The cationic Rp stereoisomers showed improved duplex-forming ability against ssDNA, triplex-forming ...