Benzamides derived from 1, 2-diaminocyclopropane as novel ligands for human D 2 and D 3 dopamine receptors

…, S Kefi, V Audinot, MJ Millan, M Langlois

Index: Yang, Donglai; Kefi, Slaheddine; Audinot, Valerie; Millan, Mark-J.; Langlois, Michel Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 2 p. 321 - 327

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Citation Number: 10

Abstract

Benzamides (3a–f) derived from 4-amino-5-chloro-2-methoxybenzoic acid and either cis or trans 1, 2-diaminocyclopropane were synthesised and were evaluated in binding assays employing, bovine striatal D2 receptors, recombinant human hD2 and hD3 receptors expressed in CHO cells and rat, cortical 5-HT3 and striatal 5-HT4 receptors. The cis and trans isomers of the derivatives were isolated and characterised. The results ...