Adamantyloxycarbonyl, a New Blocking Group. Preparation of 1-Adamantyl Chloroformate1

WL Haas, EV Krumkalns, K Gerzon

Index: Haas,W.L. et al. Journal of the American Chemical Society, 1966 , vol. 88, # 9 p. 1988 - 1992

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Citation Number: 58

Abstract

Abstract: I-Adamantyl chloroformate was prepared from I-adamantanol and phosgene. The chloroformate was allowed to react with amino acids to give the corresponding 1- adamantyloxycarbonyl (t-AdOC) derivatives. Several of them could be obtained in crystalline form while the corresponding t-butyloxycarbonyl derivatives have either not been reported or have been described as oils or amorphous solids. The adamantyloxycarbonylamino acids ...