Asymmetric syntheses and absolute stereochemistry of 5, 6-dihydro-α-pyrones, a new class of potent HIV protease inhibitors

…, J Morris, SL Vander Velde, JW Strohbach…

Index: Judge; Phillips; Morris; Lovasz; Romines; Luke; Tulinsky; Tustin; Chrusciel; Dolak; Mizsak; Watt; Vander Velde; Strohbach; Gammill Journal of the American Chemical Society, 1997 , vol. 119, # 15 p. 3627 - 3628

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Citation Number: 44

Abstract

Inhibition of the HIV protease enzyme, which plays a key role in viral maturation, represents a promising therapeutic strategy for treatment of the escalating problem of HIV infection. 1-4 At Pharmacia & Upjohn we have developed two classes of low molecular weight HIV protease inhibitors,