Electron transfer from nitrogen in microsomal oxidation of amine and amide. Simulation of microsomal oxidation by anodic oxidation

T Shono, T Toda, N Oshino

Index: Shono,, Tatsuya; Toda, Toshiki; Oshino, Nozomu Journal of the American Chemical Society, 1982 , vol. 104, # 9 p. 2639 - 2641

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Citation Number: 72

Abstract

6 a No other N-dealkylated metabolites such as primary amines and amides were detected. Anodic oxidation and the incubation of substrates with liver microsomes of a rat were carried out five times for each substrates. The product ratios (Ndemethylation/N-dealkylation) were given as means iSD. age of the RN bond was observed in the anodic oxidation of the substrate 3, the ratio (cleavage of RN bond/N-dealkylation) being less than 1, 2, and 3 ...