(Belo. C kh. Acto, 8%, 2489 (1949)) for the preparation of Demerol and a numbrr of its homologs. chloride with the formation of 1-methyl-4-phenyl-4-cyanohexamethylenimine (IV). Hydrolysis and esterification of IV yielded l-methyl-4-phenyl-4- carbethoxyhexamethylenimine (V) which was converted by lithium aluminum hydride into l- methyl-4-phenyl-4-(hydroxymethyl)-hexamethylenimine (VI). The alcohol VI was ...
