Insulin Peptides. XII. Human Insulin Generation by Combination of Synthetic A and B Chains1

PG Katsoyannis, A Tometsko…

Index: Katsoyannis,P.G. et al. Journal of the American Chemical Society, 1966 , vol. 88, # 1 p. 166 - 167

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Citation Number: 48

Abstract

[mp 257" dec;[a]" D-30.85'(c 1, DMF)(Anal. Calcd for C63H9~ N1~ 017S2: Cy 57.2; H, 6.80; N, 10.6. Found: C, 57.2; H, 6.62; N, 10.1); after HBr in TFA treatment: Rf6 0.71, R? 4.39 X His; amino acid analysis after acid hydrolysis: thrl. osero. s-gluz. zglyl. lvalo. 8ileuo. 8S- benzylcysteine~. 9], which on treatment with hydrazine afforded the respective hydrazide (VI): mp 258" dec;[aI2'D-20.0"(c 1, hexamethylphosphoramide)(Anal. Calcd for C62H90- ...