European journal of medicinal chemistry

Synthesis and biological evaluation of 3, 6-disubstituted [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole derivatives as a novel class of potential anti-tumor agents

DA Ibrahim

Index: Ibrahim European Journal of Medicinal Chemistry, 2009 , vol. 44, # 7 p. 2776 - 2781

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Citation Number: 121

Abstract

A new series of 3, 6-disubstituted triazolo [3, 4-b] thiadiazole derivatives have been synthesized by simple, high yielding routes. The key step in the construction of the triazolo [3, 4-d] thiadiazole nucleus involves the reaction of 4-amino-5-substituted [1, 2, 4] triazole-3- thiol with carbon disulphide, 4-amino benzoic acid,(2-amino [1, 3] thiazole-4-one-5-yl) acetic acid, and (1H-pyrazolo [3, 4-d] pyrimidine-2, 4-dithione-5-yl) acetonitrile. The newly ...