Synthesis and antimicrobial activity of symmetrical two-tailed dendritic tricarboxylato amphiphiles

EW Sugandhi, JO Falkinham, RD Gandour

Index: Sugandhi, Eko W.; Falkinham III, Joseph O.; Gandour, Richard D. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 11 p. 3842 - 3853

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Citation Number: 13

Abstract

Two series of water-soluble, symmetrical two-tailed homologous dendritic amphiphiles— R2NCONHC ((CH2) 2COOH) 3, 2 (n, n), and R2CHNHCONHC ((CH2) 2COOH) 3, 3 (n, n), where R= n-CnH2n+ 1—were synthesized and compared to R ″NHCONHC ((CH2) 2COOH) 3, 1 (n), R ″= n-CnH2n+ 1, to determine whether antimicrobial activity was influenced by total or individual alkyl chain lengths, and whether antimicrobial activity ...