In connection with a synthesis project, we were interested in testing the palladium-mediated coupling reaction of a 2-unsubstituted 4-halooxazole. However, no prior example of this specific structural type could be found in the literature. Electrophilic halogen sources do react with oxazoles at C-4, but this option is limited by functional group compatibility issues and by competing attack at C-2 and C-5. 1 An alternative approach was sought that would ...
