Synthesis and biological evaluation of 6, 7-disubstituted 4-aminopyrido [2, 3-d] pyrimidines as adenosine kinase inhibitors

RJ Perner, CH Lee, M Jiang, YG Gu…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 11 p. 2803 - 2807

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Citation Number: 33

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Medicinal chemistry efforts directed at optimizing the potency and improving the membrane permeability of these AK inhibitors was initiated ... While they share similar calculated physical chemical properties (solubility, clog P, etc), it is this ...