Copper-Catalyzed Electrophilic Carbofunctionalization of Alkynes to Highly Functionalized Tetrasubstituted Alkenes

MG Suero, ED Bayle, BSL Collins…

Index: Suero, Marcos G.; Bayle, Elliott D.; Collins, Beatrice S. L.; Gaunt, Matthew J. Journal of the American Chemical Society, 2013 , vol. 135, # 14 p. 5332 - 5335

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Citation Number: 82

Abstract

Copper catalysts enable the electrophilic carbofunctionalization of alkynes with vinyl-and diaryliodonium triflates. The new process forms highly substituted alkenyl triflates from a range of alkynes via a pathway that is opposite to classical carbometalation. The alkenyl triflate products can be elaborated through cross-coupling reactions to generate synthetically useful tetrasubstituted alkenes