Conformations, conformational preferences, and conformational exchange of N′-substituted N-acylguanidines: intermolecular interactions hold the key

…, M Keller, P Igel, A Buschauer…

Index: Ghorai, Prasanta; Kraus, Anja; Keller, Max; Goette, Carsten; Igel, Patrick; Schneider, Erich; Schnell, David; Bernhardt, Guenther; Dove, Stefan; Zabel, Manfred; Elz, Sigurd; Seifert, Roland; Buschauer, Armin Journal of Medicinal Chemistry, 2008 , vol. 51, # 22 p. 7193 - 7204

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Citation Number: 13

Abstract

Guanidine and acylguanidine groups are crucial structural features of numerous biologically active compounds. Depending on the biological target, acylguanidines may be considered as considerably less basic bioisosteres of guanidines with improved pharmacokinetics and