Synthesis of 2-amino-4-(7-azaindol-3-yl) pyrimidines as cyclin dependent kinase 1 (CDK1) inhibitors

S Huang, R Li, PJ Connolly, S Emanuel…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 18 p. 4818 - 4821

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Citation Number: 25

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Solubilizing amino side chains were installed using the chemistry shown in Scheme 2. The hydroxyl compound 5o was reacted with methanesulfonyl chloride to generate mesylate 6, which was then treated with various amines to give ...