Synthesis of N2??[(S)??1??carboxy??3??phenylpropyl]??L??lysyl??L??proline (lisinopril)

…, AW Douglas, DL Ondeyka, LG Payne…

Index: Wu; Douglas; Ondeyka; Payne; Ikeler; Joshua; Patchett Journal of pharmaceutical sciences, 1985 , vol. 74, # 3 p. 352 - 354

Full Text: HTML

Citation Number: 31

Abstract

M. T. Wu”, A. W. DOUGLAS, DL ONDEYKA, L. G. PAYNE, ... AA PATCHETT Received June 25, 1984, from Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065. ... Abstract 0 The synthesis and some of the spectral properties of N2- [(S)-l-carboxy-3-phenylpropyl]-~-lysyl -~-proline (lisinopril, MK-521) are described. This compound inhibits angiotensin-converting enzyme with anlCsoof1.2x lO-'M. ... Angiotensin-converting enzyme (peptidyldipeptide ...