Zeo??Click Chemistry: Copper (I)–Zeolite??Catalyzed Cascade Reaction; One??Pot Epoxide Ring??Opening and Cycloaddition

…, BM Reddy, J Sommer, P Pale

Index: Boningari, Thirupathi; Olmos, Andrea; Reddy, Benjaram M.; Sommer, Jean; Pale, Patrick European Journal of Organic Chemistry, 2010 , # 33 p. 6338 - 6347

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Citation Number: 28

Abstract

Abstract Copper (I)-modified zeolites, especially Cu I–USY, proved to be very efficient catalysts in multi-component reactions of epoxides with sodium azide and terminal alkynes. Such catalysts allow highly regio-and stereoselective syntheses ofhydroxymethylated triazoles. These heterogeneous, modified zeolites can easily be recovered and reused. Moreover, the cascade reaction was best performed in water at room temperature, ...