Novel fluorescent risedronates: Synthesis, photodynamic inactivation and imaging of Bacillus subtilis

…, KW Yang, L Feng, JM Xiao, CC Liu, YL Zhang…

Index: Zhou, Li-Sheng; Yang, Ke-Wu; Feng, Lei; Xiao, Jian-Min; Liu, Cheng-Cheng; Zhang, Yi-Lin; Crowder, Michael W. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 4 p. 949 - 954

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Citation Number: 5

Abstract

Novel fluorescently-labeled conjugates of risedronate were synthesized using an epoxide linker, enabling conjugation of risedronate via its pyridyl nitrogen with the aromatic succinimidyl esters. The compounds were characterized by using 1H NMR, 13C NMR, 31P NMR, UV–vis and fluorescence emission spectroscopies. Biological activity assays showed that the conjugates 14 and 15 exhibited photodynamic inactivation of Bacillus subtilis ( ...