3-O-alkylascorbic acids as free radical quenchers. 3. Protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats

Y Nihro, S Sogawa, A Izumi, A Sasamori…

Index: Nihro, Yasunori; Sogawa, Satoshi; Izumi, Akihiro; Sasamori, Akihiro; Sudo, Tadamitsu; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 9 p. 1618 - 1623

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Citation Number: 33

Abstract

Structural modification of ascorbic acid by substitution of the 3-hydroxy group with lipophilic moieties has dowed the development of agenta for treating reperfusion injury. These seoorbic acid derivativea inhibited lipid peroxidation, and some of them also reduced coronary reperfusion-induced arrhythmias in anesthetized rata. We found that 3-04 (dodecyl~ bonyl) methyl] ascorbic acid (8) was protective against reperfusion injury ...