Convenient access to trifluoromethanol

KO Christe, J Hegge, B Hoge…

Index: Christe, Karl O.; Hegge, Joachim; Hoge, Berthold; Haiges, Ralf Angewandte Chemie - International Edition, 2007 , vol. 46, # 32 p. 6155 - 6158

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Citation Number: 19

Abstract

With the exception of cyclo-C4F7OH,[1] alcohols possessing a fluorine atom on the α-carbon atom are unstable and undergo facile HF elimination. Therefore, it is not surprising that the most simple perfluorinated alcohol, trifluoromethanol (CF3OH), was synthesized by Seppelt only in 1977.[2] His synthesis of CF3OH involved the reaction of a positively and a negatively polarized chlorine ligand at Ą1208C [Eq.(1)].