A rapid preparation of compounds (1–24), with the objective of discovering novel and potent anti-inflammatory agent. All the compounds exhibited anti-inflammatory and analgesic activities at the dose 50mg/kg po The compound 1-(2′, 4′-Chloroacridine-9′-yl)-3-(5′- pyridine-4-yl)-(1, 3, 4-oxadiazol-2-yl-thiomethyl)-pyrazole-5-one 24 showed better anti- inflammatory and analgesic activities at the three graded dose of 25, 50 and 100mg/kg po
