Iron-containing ligands targeting the human histamine H3 receptor (h H3R) were prepared. The compounds contain ferrocene sandwich complexes coupled via different linkers to a basic h H3R antagonist/inverse agonist pharmacophore. In a click chemistry approach, a triazole was successfully inserted as a new linking element. Two ferrocenylmethylamines and a ferrocenyltriazole were the most affine h H3R ligands within this series, showing ...
