Synthesis of the novel amino acid 4??amino??3??(aminomethyl) benzoic acid (AmAbz) and its protected derivatives as building blocks for pseudopeptide synthesis

…, R Sola, F Labéguère, P Jouin

Index: Pascal, Robert; Sola, Regine; Labeguere, Frederic; Jouin, Patrick European Journal of Organic Chemistry, 2000 , # 22 p. 3755 - 3761

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Citation Number: 5

Abstract

Abstract 4-Amino-3-(aminomethyl) benzoic acid (1)(AmAbz) is a novel unnatural amino acid with promise in applications as a building block for the synthesis of peptidomimetics and as a scaffold for combinatorial chemistry. It was efficiently synthesized in three steps (63% overall yield) from 4-aminobenzoic acid, by means of regioselective amidomethylation with hydroxymethylphthalimide. AmAbz (1) contains three distinct functionalities which could ...