Characterization of Nα??Fmoc??protected dipeptide isomers by electrospray ionization tandem mass spectrometry (ESI??MSn): effect of protecting group on …

…, B Raju, R Srinivas, VV Sureshbabu…

Index: Ramesh; Raju; Srinivas; Sureshbabu; Vishwanatha; Hemantha Rapid Communications in Mass Spectrometry, 2011 , vol. 25, # 14 p. 1949 - 1958

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Citation Number: 5

Abstract

Abstract A series of positional isomeric pairs of Fmoc-protected dipeptides, Fmoc-Gly-Xxx- OY/Fmoc-Xxx-Gly-OY (Xxx= Ala, Val, Leu, Phe) and Fmoc-Ala-Xxx-OY/Fmoc-Xxx-Ala-OY (Xxx= Leu, Phe)(Fmoc=[(9-fluorenylmethyl) oxy] carbonyl) and Y= CH 3/H), have been characterized and differentiated by both positive and negative ion electrospray ionization ion- trap tandem mass spectrometry (ESI-IT-MS n). In contrast to the behavior of reported ...