e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist. alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

…, E Nielsen, P Krogsgaard-Larsen

Index: Hansen; Lauridsen; Nielsen; Krogsgaard Larsen Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 901 - 903

Full Text: HTML

Citation Number: 38

Abstract

The enantiomers of the glutamic acid central nervous system receptor agonist a-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) were prepared via kinetic resolution of the racemic N-acetylated 3-methoxy derivative by reusable, immobilized aminoacylase. L- ...

(R)-2-amino-3-(3-methoxy-5-methylisoxazol-4-yl)propanoic acid Structure

(R)-2-amino-3-(...

~62%

3-(3-Hydroxy-5-methyl-1,2-oxazol-4-yl)-L-alanine hydrobromide (1: 1) Structure

3-(3-Hydroxy-5-...

diethyl acetamido[(3-methoxy-5-methylisoxazol-4-yl)methyl]malonate Structure

diethyl acetami...

~%

3-(3-Hydroxy-5-methyl-1,2-oxazol-4-yl)-L-alanine hydrobromide (1: 1) Structure

3-(3-Hydroxy-5-...

(+/-)-OMe-AMPA Structure

~%

3-(3-Hydroxy-5-methyl-1,2-oxazol-4-yl)-L-alanine hydrobromide (1: 1) Structure

3-(3-Hydroxy-5-...

(RS)-α-(acetylamino)-3-methoxy-5-methyl-4-isoxazolepropionic acid Structure

(RS)-α-(acetyla...

~%

3-(3-Hydroxy-5-methyl-1,2-oxazol-4-yl)-L-alanine hydrobromide (1: 1) Structure

3-(3-Hydroxy-5-...

(R)-2-acetamido-3-(3-methoxy-5-methylisoxazol-4-yl)propanoic acid Structure

(R)-2-acetamido...

~67%

3-(3-Hydroxy-5-methyl-1,2-oxazol-4-yl)-D-alanine hydrobromide (1: 1) Structure

3-(3-Hydroxy-5-...

diethyl acetamido[(3-methoxy-5-methylisoxazol-4-yl)methyl]malonate Structure

diethyl acetami...

~%

3-(3-Hydroxy-5-methyl-1,2-oxazol-4-yl)-D-alanine hydrobromide (1: 1) Structure

3-(3-Hydroxy-5-...

(+/-)-OMe-AMPA Structure

~%

3-(3-Hydroxy-5-methyl-1,2-oxazol-4-yl)-D-alanine hydrobromide (1: 1) Structure

3-(3-Hydroxy-5-...

(RS)-α-(acetylamino)-3-methoxy-5-methyl-4-isoxazolepropionic acid Structure

(RS)-α-(acetyla...

~%

3-(3-Hydroxy-5-methyl-1,2-oxazol-4-yl)-D-alanine hydrobromide (1: 1) Structure

3-(3-Hydroxy-5-...

Enantioselective Synthesis of (S)-2-Amino-3-(3-Hydroxy-5-met...

[Amici, Raffaella; Pevarello, Paolo; Colombo, Maristella; Varasi, Mario Synthesis, 1996 , # 10 p. 1177 - 1179]

Enantioselective Synthesis of (S)-2-Amino-3-(3-Hydroxy-5-met...

[Amici, Raffaella; Pevarello, Paolo; Colombo, Maristella; Varasi, Mario Synthesis, 1996 , # 10 p. 1177 - 1179]

Enantioselective Synthesis of (S)-2-Amino-3-(3-Hydroxy-5-met...

[Amici, Raffaella; Pevarello, Paolo; Colombo, Maristella; Varasi, Mario Synthesis, 1996 , # 10 p. 1177 - 1179]

Enantioselective Synthesis of (S)-2-Amino-3-(3-Hydroxy-5-met...

[Amici, Raffaella; Pevarello, Paolo; Colombo, Maristella; Varasi, Mario Synthesis, 1996 , # 10 p. 1177 - 1179]

Enantioselective Synthesis of (S)-2-Amino-3-(3-Hydroxy-5-met...

[Amici, Raffaella; Pevarello, Paolo; Colombo, Maristella; Varasi, Mario Synthesis, 1996 , # 10 p. 1177 - 1179]