4-Phenyl-and 4-heteroaryl-4-anilidopiperidines. A novel class of analgesic and anesthetic agents

LV Kudzma, SA Severnak, MJ Benvenga…

Index: Kudzma; Severnak; Benvenga; Ezell; Ossipov; Knight; Rudo; Spencer; Spaulding Journal of Medicinal Chemistry, 1989 , vol. 32, # 12 p. 2534 - 2542

Full Text: HTML

Citation Number: 32

Abstract

The incorporation of the 4-phenylpiperidine pharmacophore found in morphine into 4- anilidopiperidines related to fentanyl (1) led to a novel class of potent opioid analgesic and anesthetic agents with a favorable pharmacological profile. The synthesis, analgesic activity, and anesthetic properties of a series of 4-phenyl-4-anilidopiperidines (13-29) are discussed. Isosteric replacement of the phenyl by various heteroaryl substituents extended the series ...